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Human epidemiological data have not confirmed the rodent signal, but GLP-1 agonists remain contraindicated in patients with a personal or family history of MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

This new medication may help reduce the effects of GLP-1-based drugs on muscle strength and therefore improve functionality even further compared to someone not on the new medication who is just taking tirzepatide. Writing in the journal Nature Medicine, researchers in the US reported how they randomly divided 102 participants into two groups, with 51 given apitegromab alongside tirzepatide, and the other 51 given a placebo with tirzepatide