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Concerning anemia, unless CKD and ESRD patients show significant folate depletion, additional supplementation of folic acid does not appear to have a beneficial effect on erythropoiesis or on responsiveness to Recombinant Human Erythropoietin (rHuEPO) therapy

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thus, modulators of the Wnt/-catenin pathway have emerged to improve the efficacy of different immunotherapeutic agents in combination therapy, a finding that has already been researched in preclinical models

However, hyperglycemia, in a GLUT2-dependent manner, can influence the mucus and alter the integrity of adherence and tight junctions between intestinal epithelial cells of diabetic mice