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For example, Wegovy , one of the most well-known GLP-1 medications, helped participants lose an average of 15% of their body weight when combined with healthy lifestyle changes

What the new mechanism is: GLP-1 : appetite regulation, improved glucose control GIP : incretin effects that may augment metabolic benefits Glucagon receptor activity : potentially influences energy expenditure and fat metabolism (while requiring careful balancing of tolerability and metabolic effects) What results look like (so far): Phase 2 (48 weeks) published in NEJM showed substantial mean weight reductions (with higher doses showing very large effects)

Availability can change quickly if regulations shift

Gentile S, Strollo F, Ceriello A, Group A-OITS