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The summary-level data of Genome-Wide Association Studies (GWASs) used in Mendelian randomization study can be accessed by the FinnGen ( and GTEx ( Abbreviations GLP-1 RAs: Glucagon-like peptide-1 receptor agonists DR: Diabetic retinopathy MR: Mendelian randomization HR: Hazard ratio SMR: Summary-data-based Mendelian randomization OR: Odds ratio CI: Confidence interval CVOTs: Cardiovascular outcome trials ICD-10: International Classification of Diseases, Revision 10 ATC: Anatomical Therapeutic Chemical DDD: Defined daily dose cis-eQTL: Cis-expression quantitative trait loci GWAS: Genome-Wide Association Study CVD: Cardiovascular disease SD: Standard deviation SNP: Single nucleotide polymorphism MAF: Minor allele frequency HEIDI: Heterogeneity in dependent instruments References Shah AR, Gardner TW

While significant weight loss always carries a risk of losing some lean mass, the clinical data for GLP-1-based therapies, including Retatrutide, suggests a favorable ratio of fat mass loss to lean mass loss

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