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This milestone reinforces Eccogenes position as an innovator in advancing novel, differentiated oral therapies for cardiometabolic diseases with broad commercial potential. Sharon Barr, Executive Vice President, BioPharmaceuticals R&D at AstraZeneca, commented: The start of this Phase 1b trial in China marks an important milestone in the extensive clinical program for AZD5004/ECC5004, an oral small molecule GLP-1RA which has significant potential as part of our extensive CVRM portfolio

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In a thorough review, the use of probiotic supplements was able to significantly reduce the occurrence of pouchitis, or inflammation of the reservoir formed upon surgical creation of an ilio-anal pouch, by 96% compared to placebo after surgery among ulcerative colitis patients (Elahi 2008)

Overall, the lower VTE, PE, and DVT risk observed versus DPP-4i provides a reassuring safety signal for modern glucose-lowering agents [14, 21, 23, 24]