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Key Factors Contributing to Melasma Melasma does not have a single cause but rather arises from multiple interrelated triggers: Hormonal changes: Pregnancy, birth control pills, and hormone replacement therapy can stimulate melanin overproduction

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Previous studies have shown that the stronger adsorption of O 2 on Fe-N 3 than Fe-N 4 , indicating the significantly larger oxygen affinity of pFeSAN with the unsaturated Fe-N 3 coordination than that of FeSAN with Fe-N 4 unit 37,39