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Who may benefit from GLP-1 medications for heart disease prevention GLP-1 medications arent for everyone, but evidence suggests several groups may see meaningful cardiovascular benefit: People with established cardiovascular disease , such as a prior heart attack, stroke, or blocked arteries People with type 2 diabetes or metabolic syndrome , a combination of risk factors like belly fat, high blood pressure, and high blood sugar People with obesity and multiple heart risk factors, even without diabetes If your 10-year heart risk is moderate to high, a GLP-1 may be one more way to lower that risk, Le says