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These can develop before or persist despite treatment, underscoring the importance of therapeutic monitoring

Conclusions and Implications The established 3D imaging and quantification approach provides a powerful tool for evaluating the therapeutic efficacy of antifibrotic compounds and studying the cellular and pathological mechanisms underlying cardiovascular diseases

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Given that both of these studies were in patients with OA of the knee (a load-bearing joint), it is likely that a significant proportion of the efficacy observed was due to the significant loss of body weight, reducing pathological joint loading