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Native rhIGF-1 (mecasermin, brand name Increlex) is FDA-approved only for the long-term treatment of growth failure in pediatric patients with severe primary IGF-1 deficiency or with GH gene deletion who have developed neutralizing antibodies to GH

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Generally, mitochondrial respiration control, including oxygen consumption rate (OCR) and respiratory control ratio (RCR), is utilized to measure the mitochondrial function in diverse cell populations (Lebiedzinska et al., 2010

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