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Dose Selection: The trials evaluated doses ranging from 0.25 mg to 54 mg, with higher doses showing increased gastrointestinal effects

Knowing when to reduce dose or discontinue Not every side effect requires discontinuation, but some warrant reducing dose or stopping use

[34] Neurological symptoms: sensory or motor deficiencies (absent reflexes, diminished vibration or soft touch sensation) and subacute combined degeneration of the spinal cord

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