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Accordingly, a retrospective analysis of SUSTAIN-6 examined the role of preexisting advanced retinopathy and the induction of rapid reductions in plasma glucose and HbA 1c and found retinopathy complications mainly in those with preproliferative or proliferative retinopathy at baseline who experienced a large reduction in HbA 1c within 16 weeks after initiation of semaglutide (83)