An achievement of HBsAg loss represents the hallmark of resolution of HBV infection and is a therapeutic goal for a functional cure
CF transmembrane conductance regulator dysfunction also impairs immune responses to infection by neutrophils, macrophages, and T lymphocytes (61, 120122)
Complications related to AP can be vast, including pseudocysts, necrosis, and infections, and can be potentially devastating with the inflammation leading to acute respiratory distress syndrome, multisystem organ failure, and even death [12]
Up to now, powerful genetic tools allowed clarification of the significance, dispensability and potential of cystine transporters for ferroptotic cell death in PDAC and breast cancer ( via xCT ( A high extracellular glutamate concentration was one of the first xCT inhibitors described but a few years later, erastin (standing for eradicator of RAS and small T antigen-expressing cells) was identified by Stockwell's group in RAS-mutated cancer cell lines as inhibitor of xCT transport ( in vitro studies as efficient inducer of ferroptosis in many different cancer types, including breast, PDAC, lymphoma, renal, brain and ovarian cancers (50, 51) and sorafenib (52)
