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GPx reduce potentially damaging reactive oxygen species (ROS), such as hydrogen peroxide and lipid hydroperoxides, to harmless products like water and alcohols by coupling their reduction with the oxidation of glutathione ( Figure 2 ) (73, 74)

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214,215 A systematic review of 12 clinical trials found that CoQ10 supplementation in patients with CKD significantly reduced blood levels of malonaldehyde, a marker of oxidative stress, and high-sensitivity C-reactive protein (hs-CRP), which is a marker of systemic inflammation