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In the model presented to NICE, the company said those in the trial were provided with advice including leaflets on healthy diet, smoking cessation and physical activity which is similar to what already happens in cardiovascular risk management, so they had not included a separate cost for this

doi:10.3892/or.2013.2504

In addition, a few states mentioned concerns regarding adherence as well as challenges developing clinical criteria, including wanting to provide lifestyle change programs or nutrition services in tandem with coverage, in their states decision not to cover obesity drugs at this time

Phentermine's sympathomimetic mechanism contraindications include cardiovascular disease, hyperthyroidism, and history of substance abuse