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Currently, the FDA is advising against the use of GLP1 agonists in people at risk for MTC or MEN2 syndrome ( N Engl J Med

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The L-Cell Function L-cells perform several critical metabolic functions: GLP-1 Production: Convert proglucagon (precursor protein) into active GLP-1 hormone Nutrient Sensing: Detect proteins, fats, and carbohydrates passing through the intestine Gut-Brain Communication: Release peptide YY (PYY) that signals satiety to the brain Metabolic Regulation: Respond to short-chain fatty acids produced by gut bacteria Research demonstrates that L-cell density and function can be influenced by dietary patterns, gut microbiome composition, and specific nutrients