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Although clinically significant cholestasis is rare in DJS, neonatal cholestasis is the most well-documented form of overt cholestasis in DJS

Individuals often observe the following: Haggard, hollowed-out appearance to the face Eyes appear sunken in their sockets Sagging skin around the neck and jawline Alterations in the size of chin, cheeks and lips Appearance of additional wrinkles When these manifestations reach serious proportions, some individuals actually choose to undergo facial reconstructive surgery to remedy their appearance

Nrf2 and ferroptosis: a new research direction for neurodegenerative diseases