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Ultimately, the goal for older adults should focus on optimising health, function, and quality of life rather than achieving arbitrary weight targets, recognising that modest weight loss or weight stabilisation may represent successful outcomes in this population

This enzyme has the task of combining the amino acids glutamate and cysteine to form Glyteine, which is eventually needed to produce glutathione by the next enzyme GS

The upregulation of these enzymes directly leads to excessive breakdown of core ECM components in cartilage, such as type II collagen and aggrecan