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doi: 10.3389/fphar.2021.632295 Received 07 December 2020 Accepted 13 April 2021 Published 10 June 2021 Volume 12 - 2021 Edited by Chiara Bianca Maria Platania, University of Catania, Italy Reviewed by Doreen Schmidl, Medical University of Vienna, Austria Francesca Lazzara, University of Catania, Italy Updates Copyright 2021 Zlatar, Kokot, Vuletic, Masnec, Kralj, Perisa, Barisic, Radic, Milanovic, Drmic, Seiwerth and Sikiric

Compression- or actomyosin-mediated nuclear flattening alters the permeability across nuclear pore complexes, resulting in active nuclear import of key transcription regulators such as YAP, SMAD3, Twist1, and Snail [124, 125]

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Pregnancy: Tirzepatide should be discontinued at least two months before planned pregnancy and should not be used during pregnancy or breastfeeding