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Although GSSG represents approximately 1% of the total glutathione in the cell under basal conditions, a striking increase is found in cells undergoing oxidative stress

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From an immunological perspective, these associations arise from a breakdown in self-tolerance mediated by overlapping T-cell and B-cell autoreactivity, shared cytokine pathways (e.g., IFN-, IL-18), and common antigen-presenting HLA alleles