ALT and AST levels are not reliable indicators of the presence or severity of NAFLD.(14) ALT and AST levels are not reliable indicators of the presence or severity of NAFLD. RISK STRATIFICATION Liver biopsy is the gold standard to stratify NAFLD and the only way to identify histologic ballooning to diagnose NASH
It mimics the GLP-1 hormone, helping regulate blood sugar, slow digestion, and reduce hunger
Other loci, such as glucokinase regulator (GCKR) and membrane bound O-acyltransferase domain-containing 7 (MBOAT7), influence glucose metabolism, phospholipid remodeling, and insulin sensitivity, highlighting the tight link between metabolic dysfunction and liver injury
The activation of PPAR, therefore, maintains IS and exhibits an anti-inflammatory function, whereas IR causes impaired adipogenesis and increased risk of T2DM [44, 45]