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Ongoing monitoring for any emerging concerns remains prudent, as with any medication

This initial dose helps your body adjust to the medication and can minimize side effects, particularly digestive issues such as nausea and diarrhea

The resting tension of aortic rings was adjusted to 1.0 g

Saxagliptin has also been evaluated in five additional trials in patients with type 2 diabetes mellitus: an active-controlled trial comparing add-on therapy with saxagliptin to glipizide in 858 patients inadequately controlled on metformin HCl alone, a trial comparing saxagliptin to placebo in 455 patients inadequately controlled on insulin alone or on insulin in combination with metformin HCl, a trial comparing saxagliptin to placebo in 257 patients inadequately controlled on metformin HCl plus a sulfonylurea, a trial comparing saxagliptin to placebo in 315 patients inadequately controlled on dapagliflozin and metformin HCl, and a trial comparing saxagliptin to placebo in 170 patients with type 2 diabetes mellitus and moderate or severe renal impairment or ESRD