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The integrated transcriptome and metabolome analysis results showed that melatonin regulated the b-alanine metabolism, monoterpene biosynthesis, and glutathione metabolism pathways, and increased the contents of spermine and spermidine in cells by promoting the expression of genes such as HannXRQ_Chr07g0195521 and HannXRQ_Chr03g0093321 in the b-alanine metabolic pathway

Lnn ME, Hudemann C, Berndt C, Cherkasov V, Capani F, Holmgren A, et al

10.1056/NEJMra2026131 N Engl J Med

Inactivation of GPX4, through depletion of GSH or by using GPX4 inhibitors, ultimately results in overwhelming lipid peroxidation and cell death in various non-erythroid cells (Yang et al., 2014