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The cerebellum also undergoes microglia-dependent pruning of surplus climbing fiber synapses for refined motor system (Nakayama et al., 2018)

CDI triggers metabolic shifts that could facilitate steatosis and inflammation, suggesting that CDI could be a risk factor for metabolic liver diseases

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The inability to appropriately sense, buffer, or correct proteotoxic stress results in the accumulation of misfolded proteins, organelle dysfunction, aberrant signaling, and ultimately tissue failure