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Developed at the Russian Academy of Sciences, it has been used clinically in Russia for stroke, dyscirculatory encephalopathy, and optic nerve atrophy

Ingredients (INCI) Aqua (Water), Carnitine, Propylene Glycol, Methylsilanol Mannuronate, Troxerutin, Benzyl Alcohol, Cynara Scolymus Leaf Extract, Centella Asiatica Extract, Melilotus Officinalis Extract, Hedera Helix (Ivy) Leaf/Stem Extract, Ginkgo Biloba Leaf Extract, Camellia Sinensis Leaf Extract, Aesculus Hippocastanum (Horse Chestnut) Seed Extract, Phenoxyethanol, Ethylhexylglycerin, Sorbic Acid.

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Berberine can also be used in combination with other drugs such as levetiracetam and curcumin to enhance its neuroprotective effect by reducing inflammation and oxidative stress (Lin et al., 2020