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PMID: 15611387, DOI: 10.1161/01.cir.0000150389.35936.4d

Depression can manifest with a range of combined physical and psychological symptoms, including: sadness or hopelessness constant difficulty concentrating or making decisions fatigue or low energy loss of interest in hobbies and activities that you used to enjoy persistent feelings of guilt or worthlessness agitation difficulty sleeping unwanted changes in appetite and body weight loss of sexual desire thoughts of suicide suicide attempts A healthcare professional typically diagnoses depression when five or more of these symptoms are present for at least 2 consecutive weeks

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Skin conditions such as irritation, rashes, or occasional infection can develop where the overhanging tissue traps moisture, particularly if the area isnt kept clean and aired