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Clinical research demonstrates that extended-interval dosing can deliver sustained appetite suppression when properly calibrated, though individual response varies based on metabolic factors and genetic predisposition

These findings, and recent evidence that a delayed-release formulation of metformin with minimal systemic absorption retains its glucose-lowering efficacy [15], suggest that the glucose-lowering effects of metformin are strongly influenced by effects on the gut

Maquart FX, et al