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Recently, in addition to the central maintenance of food intake, GLP-1R signaling has begun to be considered in the context of the regulation of the stress response, as it is indicated that it can activate both the hypothalamicpituitaryadrenal (HPA) axis as well as the sympathetic nervous system [15, 16]
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Despite the need for additional work to elucidate the potential underlying mechanisms of these associations, low vitamin B12 levels should be considered as a possible culprit in certain subpopulations of patients experiencing sleep disturbances
The gut hormones PYY3-36 and GLP-17-36 amide reduce food intake and modulate brain activity in appetite centers in humans
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