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Design of daLUXendin544 and daLUXendin660 Structureactivity relationships and cryo-electron microscopy show that the binding affinity and efficacy of GLP1R agonists, GIPR agonists and dual agonists are determined by amino acids closer to the N-terminus 24,25,26,27

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2.1 Pharmacological effects METH is a lipophilic compound that rapidly crosses the blood-brain barrier (BBB) and accumulates in the brain