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The authors concluded that once-weekly tirzepatide induced superior glycaemic control compared with daily insulin degludec in adults with T2DM treated with metformin, with or without an SGLT2 inhibitor

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[9] The mechanism may involve GLP-1 receptor expression in the mesolimbic dopamine pathway, and early animal data support a role for GLP-1 agonists in reducing alcohol self-administration

However, the magnitude of effect differs proportionally, and consumers must calibrate expectations accordingly