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Before & After Observations Although large human trials are lacking, small case reports have appeared in alternative medicine journals

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By binding to ER in endothelial cells, estrogens induce nitric oxide (NO) release, consequently producing vasodilation (Penotti et al., 1996), and the impedance of this flow appears to be reduced after starting hormone (estrogen) replacement therapy (HRT) ( Estrogens and Neurodegenerative Diseases Experimental and clinical data suggest that estrogens have protective effects against neurodegenerative diseases (Kumar et al., 2010

Protection of hippocampal neurons from ischemia-induced delayed death by hepatocyte growth factor: a novel neurotrophic factor