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Compared with mammals, fish have a lower ability to use carbohydrates as energy sources ( Reference Wilson 73 ) , but interactions between lipid and carbohydrate metabolism have been demonstrated in fish ( Reference Polakof, Mdale and Larroquet 74 , Reference Borges, Valente and Vron 75 )

Unfortunately, the development of the combination therapy was discontinued in 2011 following commercial reassessment