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Our present findings are consistent with, and extend, a growing body of evidence for the broad role of the OB as a key metabolic hub able to both detect and control variations of insulin and glucose 33

The reduction in LFC was significantly correlated (p0.0006) with baseline LFC (=-0.71), reductions in visceral adipose tissue, and abdominal subcutaneous adipose tissue in the tirzepatide groups [63]

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The expression of the growth factor independence1 (Gfi1) transcription factor in Paneth and Goblet cell precursors prevents their conversion into EEC lineage [21]