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Nevertheless, our findings in erythrocytes and previously published in SCD cardiac tissues 46 support that, in addition to inflammation suppression 23 and fetal globin induction 31,63,64 , DMF displays anti-oxidative and ferroptosis stress effects to alleviate SCD clinical severity, and therefore, might be pursued as a new treatment option

modest increases in prolactin and cortisol levels 1

McMahon et al., 2001

In the last years, in vitro studies have shown that MPs affect cell viability, induce cell senescence, alter adipogenic cell differentiation, modify gene expression, increase reactive oxygen species production, trigger inflammatory responses, and promote osteoclastogenesis