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elegans have demonstrated that the removal of germline stem cellseither through laser ablation or genetic mutations, such as the temperature-sensitive glp-1(e2144) mutantleads to lifespan extension and significant alterations in fat metabolism in hermaphrodites 2,6,12

Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma

Along with their antioxidant properties, GLP-1 RAs also demonstrate considerable anti-inflammatory effects, further diminishing the pro-inflammatory environment that accelerates aging

The notion for combining entero-pancreatic hormone-based therapies for obesity treatment is supported by the efficacy of bariatric surgery on WL, an intervention leading to increased postprandial levels of multiple entero-pancreatic hormones [31, 32]