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Patients who feel their current dose is not working effectively should consult their prescriber about increasing to the next tier, not changing the dosing frequency

A randomized phase II study of pomegranate extract for men with rising PSA following initial therapy for localized prostate cancer

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So, a major portion of a dose of phenacetin would be rapidly metabolised to paracetamol, it seemed possible that phenacetin owed some of its antipyretic activity to its main metabolite, paracetamol, whereas its most troublesome side effect (methemoglobinemia) was due to another metabolite-phenetidine