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doi: 10.1021/bi00402a046

Ozempic is a GLP-1 receptor agonist that signals fullness and reduces appetite, while metformin is a biguanide that primarily improves insulin sensitivity

The molecular and structural/functional changes translate to (1) Tubular atrophy, podocyte hypertrophy, glomerulosclerosis, and microvascular rarefaction and (2) glomerular basement membrane thickening, nephrosclerosis, and extracellular matrix accumulation, respectively [84]