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TNF--induced DNaseII reduction might be responsible for the accumulation of dsDNA in FLSs, as TNF- stimulation decreased both the mRNA and protein levels of DNaseII (63)

[20] B12 deficiency can also affect cognition, with impaired memory and focus reported, and in severe cases, memory loss

Neurochemistry International, 44 (3), 153159

And it remains far from pharmaceutical marketing: Phase 3 trials are underway, the target NDA is Q4 2026, and patient access is theoretically not expected before 2028-2029