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Semaglutide is a GLP-1 receptor agonist that mimics the hormone glucagon-like peptide-1 (GLP-1)

This lack of absolute specificity raises concerns about off-target effects, particularly given the potential for unintended gene activation in noncardiac tissues

Women under atypical antipsychotic treatment showed to have a decreased species diversity in their gut microbiota compared to healthy controls, while men did not show to have this difference [254]

Although its a pill, Rybelsus also comes with some challenges: It must be taken daily on an empty stomach, with no eating, drinking or taking other medications for at least 30 minutes, and doctors report that it may not be as effective as injections yet still comes with side effects