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Elimination After subcutaneous injection of TOUJEO in diabetic patients, insulin glargine is metabolized at the carboxyl terminus of the B-chain with formation of two active metabolites M1 (21A-Glyinsulin) and M2 (21A-Gly-des-30B-Thr-insulin)

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The mechanisms of NP-induced neurotoxicity include the generation of free radicals, immune responses, and neuroinflammation, which can lead to cell necrosis and other adverse effects

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