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Scientific knowledge about the pharmacological actions of exogenous cannabinoids was considerably informed by the discovery of the G protein-coupled cannabinoid receptors (CB 1 and CB 2 ) and their endogenous ligands known as endocannabinoids (anandamide and 2-arachidonoylglycerol (2-AG)) which, along with their synthesis/degradation enzymes, collectively constitute the endocannabinoid system

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Accordingly, these principles have been therapeutically exploited in nanomedicine platforms designed to induce GSH-dependent ROS amplification (Fig

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2021 Jan 14;13(1):221 6

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