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Folinic acid (calcium folinate) and 5-MTHF supplementation is not recommended concurrent with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity

Although most people tolerate statins well, some may experience an increased risk of diabetes, mainly if they have a risk of the condition due to factors such as prediabetes, excess weight, or metabolic syndrome

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