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Blood Pressure and Heart Medication Considerations Semaglutide often lowers blood pressure as a secondary effect, which combines with antihypertensive drugs (like ACE inhibitors, beta-blockers, and diuretics) to potentially cause excessive drops in blood pressure

10.1080/15569543.2021.2024576 294 VickersN

While these observational findings do not prove causation, they have prompted multiple prospective clinical trials investigating semaglutide specifically for neurodegenerative conditions