From what Ive seen with clients: Thighs and glutes get smaller but weaker
Discussion Treatment with ALC for 6 months on top of simvastatin did not significantly affect SBP, insulin resistance, and lipid profile in patients with hypertension, dyslipidemia, and T2D on stable background antihypertensive and hypoglycemic therapy
Although hair loss does not typically result in physical harm, it may have significant psychosocial consequences, affecting self-esteem, quality of life, and adherence to treatment. That study also suggested that the risk of hair loss may not be fully explained by rapid or extreme weight loss alone. A similar finding was highlighted in an April 2026 Sage Journals study, which found accumulating evidence from pharmacovigilance databases and clinical cohorts suggests an increased risk of hair loss with certain GLP-1 RAs, particularly semaglutide and tirzepatide. In preventing hair loss, Netchiporouk recommends not losing the weight too quickly. If people lose one pound to one kilogram a week, that will have the hair shedding, if they dont care about the hair shedding, its OK then
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