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Drug and substance interactions: Both Phentermine and Semaglutide can lead to harmful interactions with monoamine oxidase inhibitors, weight loss stimulants like naltrexone or bupropion, alcohol, or adrenergic neuron-blocking drugs

Traditional oral supplements often undergo significant first-pass metabolism in the liver, which can reduce the amount of active compound that reaches systemic circulation

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Plus, drinking ice-cold water can help relieve any Ozempic-related nausea