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Important to note that the GLP-1 RAs group had a tendency of lower risk of uncomplicated pancreatitis (HR 0.71

This detoxification mechanism protects cellular components like Deoxyribose Nucleic Acid (DNA), proteins, and lipids from oxidative damage, which can otherwise lead to mutations and disease

however, other forms of ROS also contribute as the nitric oxide (NO) generated by NO synthases, which diffuses into mitochondria and modulates mitochondrial function by competing with O 2 at respiratory complex IV thereby slowing respiration (Collins et al., 2 O 2 in thiol oxidation modulating the function of proteins (Collins et al., 2014)

This process is facilitated by a system of numerous NRAMPtype and ABCtype manganese transport proteins