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When applying the treatment policy estimand, people treated with oral semaglutide 50mg achieved a superior weight loss of 15.1% vs a reduction of 2.4% with placebo and 84.9% achieved a weight loss of 5% or more, compared to 25.8% with placebo

Sermorelin must be administered before bedtime to synchronise with the body's natural growth hormone pulse

Additionally, the updated results (July 2023) of the tirzepatide SURMOUNT-1 trial recorded an average reduction in body weight of 22.5%

They write: The current literature supports modifying fasting recommendations for patients taking GLP-1 RAs as the most important mitigating factor