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Local GI Effects: For applications related to gut lining, oral administration may provide direct topical contact with intestinal tissues in theory

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While patients may occasionally notice swollen lymph nodes during treatment, current clinical trial data and FDA prescribing information do not establish tirzepatide as a recognized cause of lymphadenopathy

When to seek care If smelly gas lasts for a couple of weeks, especially if its accompanied by additional GI symptoms (diarrhea, abdominal pain, bloating, etc.), seek medical attention