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We also summarized ongoing clinical trials evaluating MSTN inhibitors alone or in combination with GLP-1 agonists (Table 1)

( a , b ) Cumulative distribution plot of observed percentage change from baseline over time in body weight for participants in the full analysis set during the in-trial observation period* (a) and on-treatment observation period (b)

This finding positioned GLP-1 receptor agonists not merely as metabolic drugs but as cardiovascular therapeutics, a distinction that carries particular relevance for menopausal women, whose cardiovascular risk accelerates significantly during and after the transition

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