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(4) Clinical combinations: BBR-silymarin co-administration significantly improves glycemic control (fasting glucose, HOMA-IR) and lipid profiles (TG, LDL) in diabetic patients, and decreases BMI, and the WHR in obesity patients versus BBR monotherapy [196]

Conclusions In the ZSF1 HFpEF rat model, increased dietary intake is associated with alterations in gut microbiome composition and bacterial metabolites, an impaired intestinal barrier, and changes in pro-inflammatory and health-predictive metabolic profiles

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Ferroptosisregulated by iron metabolism and lipid peroxidation (222)plays a non-redundant role in SLE/LN via multiple immune cell types: T/B-cell iron overload triggers ferroptosis to amplify autoimmunity (215, 218)