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Injecting cold water onto the peptide powder can create thermal stress that degrades sensitive amino acid sequences
A small randomized study (5) with N=60 patients where melatonin was orally administrated (3mg/day) from day 3-5 until hCG administration (oocyte collection) showed: a higher number of total oocytes (11.5 vs 6.9) higher number of mature oocyte (9% vs 4.4%) a higher rate of embryos transferred (69.3% vs 44.8%) These results were confirmed in another independent trial (6)
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